Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene
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چکیده
منابع مشابه
Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene
Takayuki Shindo, MD, PhD; Yukiko Kurihara, MD, PhD; Hiroaki Nishimatsu, MD, PhD; Nobuo Moriyama, MD, PhD; Masao Kakoki, MD, PhD; Yuhui Wang, MD; Yasushi Imai, MD, PhD; Aya Ebihara, MD, PhD; Tomoyuki Kuwaki, PhD; Ki-Hwan Ju, PhD; Naoto Minamino, PhD; Kenji Kangawa, PhD; Takatoshi Ishikawa, PhD; Minoru Fukuda; Yoshihiro Akimoto, PhD; Hayato Kawakami, PhD; Tomihiko Imai, MD, PhD; Hiroyuki Morita, ...
متن کاملVascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.
BACKGROUND Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. Levels of AM are markedly increased in the fetoplacental circulation during pregnancy, although its function there remains unknown. To clarify the physiological functions of AM, we chose a gene-targeting strategy in mice. ...
متن کاملExtreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene.
Adrenomedullin, a recently identified potent vasodilator, is expressed widely and has been suggested to have functions ranging from reproduction to blood pressure regulation. To elucidate these functions and define more precisely sites of Adm expression, we replaced the coding region of the Adm gene in mice with a sequence encoding enhanced green fluorescent protein while leaving the Adm promot...
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We reported previously that ATP2B1 was one of the genes for hypertension receptivity in a large-scale Japanese population, which has been replicated recently in Europeans and Koreans. ATP2B1 encodes the plasma membrane calcium ATPase isoform 1, which plays a critical role in intracellular calcium homeostasis. In addition, it is suggested that ATP2B1 plays a major role in vascular smooth muscle ...
متن کاملElevated blood pressures in mice lacking endothelial nitric oxide synthase.
Nitric oxide produced in endothelial cells affects vascular tone. To investigate the role of endothelial nitric oxide synthase (eNOS) in blood pressure regulation, we have generated mice heterozygous (+/-) or homozygous (-/-) for disruption of the eNOS gene. Immunohistochemical staining with anti-eNOS antibodies showed reduced amounts of eNOS protein in +/- mice and absence of eNOS protein in -...
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ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/hc4101.097111